I also wonder how it factors in a character's weapon skill vs a player's FPS skill. Just because I can manually shoot someone in the head repeatedly doesn't mean my character can do it using VATS, where a % chance to hit comes into play. Makes me wonder if they scale down the damage by your chance to hit or something if you're shooting manually. Otherwise, since I'm pretty good at FPS games, it seems like I could totally ignore gun skills for my character in Fallout 3 if my manual aim is good enough to make up for it.